ACESO's Mission

To improve survival for patients with sepsis in austere settings through the development of

Host-Based Diagnostics & Prognostics

Translate systems biology-based host biomarkers to point-of-care diagnostics.

Evidence-Based Clinical Management

Implement tools and strategies to improve clinical care and outcomes.

The Threat of Sepsis

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer M et al., 2016). The global estimate of sepsis is 30 million episodes and 6 million deaths per year, however this is likely an underestimate due to the lack of reliable data from low- and middle-income countries where 87% of the world population lives (Fleischmann C et al., 2016). In May 2017, the World Health Organization (WHO) adopted a resolution aimed to improve the prevention, diagnosis and management of sepsis illustrating the urgency of the problem (Reinhart K et al., 2017).

Founded in 2010, ACESO is a consortium consisting of U.S. Government, non-profit, academic and industry partners administered by The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.


ACESO is exploring host-based biomarkers for early recognition and individualized management of sepsis analyzing various biological signatures to increase understanding of the pathogenesis and related host response pathways associated with common and/or dangerous infectious agents.

Clinical Practice

ACESO seeks to improve clinical practices by developing evidence-based guidelines for management of clinical syndromes in patients with severe infections through clinical trials across the globe.


ACESO seeks to partner with global developers to implement point-of-care analytics to predict the best clinical course to improve patient outcome.

ACESO Research Network

What is ACESO Doing?

By facilitating and coordinating a research network of military and academic partners, ACESO aims to improve early recognition, diagnosis, and treatment of this deadly disease.

Pandemic or Mass Casualty
Pandemic or Mass Casualty
Prolonged Field Care
Prolonged Field Care
Low- to Middle Income Countries
Low- to Middle-Income Countries

Number of Sites


Clinical Protocols


Enrollment in Last 90 Days
(A/O 07Aug2023)


Total Enrollment

Contact Us

6720b Rockledge Dr., Ste 610, Bethesda, MD 20817

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